Endothelial tissue factor stimulation by proteinase 3 and elastase
نویسندگان
چکیده
منابع مشابه
Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).
Neutrophil proteinases released at sites of inflammation can affect tissue function by either activating or disarming signal transduction mediated by proteinase-activated receptors (PARs). Because PAR1 is expressed at sites where abundant neutrophil infiltration occurs, we hypothesized that neutrophil-derived enzymes might also regulate PAR1 signaling. We report here that both neutrophil elasta...
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Morihara, Kazuyuki (Shionogi Research Laboratory, Osaka, Japan). Production of elastase and proteinase by Pseudomonas aeruginosa. J. Bacteriol. 88:745-757. 1964.-Some strains of Pseudomonas aeruginosa produced elastase, but the others did not. The elastase-positive strains produced two proteinases (fractions II and III), and the elastase-negative strains produced one proteinase (fraction III). ...
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Neutrophil granulocytes form the body's first line of antibacterial defense, but they also contribute to tissue injury and noninfectious, chronic inflammation. Proteinase 3 (PR3) and neutrophil elastase (NE) are 2 abundant neutrophil serine proteases implicated in antimicrobial defense with overlapping and potentially redundant substrate specificity. Here, we unraveled a cooperative role for PR...
متن کاملInhibition of neutrophil elastase by recombinant human proteinase inhibitor 9.
Proteinase inhibitor PI9 (PI9) is an intracellular 42-kDa member of the ovalbumin family of serpins that is found primarily in placenta, lung and lymphocytes. PI9 has been shown to be a fast-acting inhibitor of granzyme B in vitro, presumably through the utilization of Glu(340) as the P(1) inhibitory residue in its reactive site loop. In this report, we describe the inhibition of human neutroph...
متن کاملVascular Endothelial Growth Factor Production is Regulated by Gene Polymorphisms
Background: Vascular endothelial growth factor (VEGF) has a key role in angiogene-sis and in transplantation. The level of VEGF is related to the differences in the DNA sequence of its promoter region. Objectives: In this study, the association between the combination of VEGF –1154 G and –2578 C alleles and VEGF production by LPS-stimulated PBMCs was investigated. In addition; the relationship ...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2001
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2001.01587.x